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U-47700 is the novel opioid, 7.5X potent than morphine.

U-47700 is an opioid analgesic drug developed by a team at Upjohn in the 1970s. U-47700 was derived from an earlier opioid AH-7921. U-47700 is selective for the µ-opioid receptor, having around 7.5 x the potency of morphine in animal models.

U-47700 is the result of a great deal of work elucidating the quantitative structure–activity relationship of the scaffold. The team looked for the key moieties which gave the greatest activity. Upjohn posted over a dozen patents on related compounds, each optimizing one moiety until they discovered that U-47700 was the most active.

U-47700 became the lead compound of selective kappa-opioid receptor ligands such as U-50488 (containing a single methylene spacer difference) and U-69,593, which share very similar structures. Its structure led to other chemists experimenting with it to see if rigid analogues would retain activity.


“I recently ran across a novel opioid substance by the name of U-47700 in search of a legal and easily accessible alternative to traditional opioids. From my understanding, it is a mu receptor agonist, suggesting that effects should closely resemble other opioids.

My very first experience, I took 20mg which is a somewhat conservative dose. Since it was my first time, and there wasn't very much information on the substance, I figured 20mg would be a good place to start. I have no opioid tolerance whatsoever, I am in pretty decent shape, and generally have a pretty good overall mindset.

20mg down the chute. This stuff tasted awful - very bitter! I sat waiting anxiously for the first effects to start coming on. No more than 20 minutes later, I start feeling a warm sensation in my stomach and a mild euphoria coming on. 'Man!' I thought to myself, 'I like this stuff already! 'As the title suggests, the effects were in fact very similar to tramadol; a substance I've had at least a few dozen experiences with. I sat there for an hour or so playing video games with my friend, and felt completely content with everything - a feeling I usually get when on opioids. It wasn't a powerful 'rush' of euphoria, if you will, but rather it's just more of a feeling of being in a wonderful mood. Another thing I noticed is that it (albeit unsurprisingly) makes you feel very relaxed and tired, and that your breathing slows down and breaths are deeper. You could easily nod off if you took a higher dose, say 40-50mg. Perhaps a dose that high may produce slight nausea, but nothing overwhelming by any means. The effects lasted for probably two or three hours before tapering off, and probably an additional hour or two before baselining completely. I had absolutely no trouble sleeping that night.

Overall, U-47700 definitely has some recreational value to it. I enjoy it as more of an end-of-the-day relaxer, but opioids by nature have an addictive property to it, so be mindful of your habits! This definitely felt safer than a lot of other things I have tried; I never noticed any feeling of toxicity to it. I would definitely recommend this to anybody looking for a good RC opioid; you won't be disappointed.”

“I received a nice white powder that seemed to smell like cocaine. I took my new accurate milligram scale and measured out 5mg and dissolved it in DI(deioized)water. I am a chemist, by the way. At least I was. Anyway, I always test a small amount first. I don't have the equipment to test it like I would normally. The first dose had no effect. Then, I measured out another 20 mg and added it to the solution. I put 0.5 ml in a syringe and I IM'ed It after 5 minutes I started to feel the warm and nice feeling of the opiate. But, as a daily opiate user I needed more. In about 30 minutes I injected the rest. Then, I felt the full effects of the substance.

It came on nicely with that warm and really good but light orgasmic feeling that I get with heroin. I was quite surprised because costing maybe $1-$2 per dose I could not believe it. I would rather have this than a roxy any day. “

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