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HEXEDRONE

N-Ethylhexedrone (commonly as Hexen) is a novel synthetic stimulant of the cathinone chemical class that produces classical stimulant effects such as stimulation, disinhibition, thought acceleration, and euphoria when administered. Its effects are believed to be caused by its activity as an NDRI (norepinephrine-dopamine reuptake inhibitor), although this has yet to be scientifically validated.

As with many of its research chemical cathinone predecessors, Hexen is known to come in the form of either a white powder or crystallized shards which users can ingest to produce a powerful, fast-acting but short-lived euphoric stimulant effects which are comparable to those produced by crack-cocaine, NEP and α-PVP-type compounds, particularly when they are insufflated, vaporized or injected.

Like other short-lived substituted cathinone compounds, Hexen has gained notoriety for its associated tendency to induce compulsive redosing and addictive behaviors in a seemingly significant percentage of its users as well the ability to readily induce paranoia, anxiety, various delusional states and stimulant psychosis when abused, taken too frequently or in excess.

Hexen was first synthesized in 2011 but became widely available in the research chemical market during late 2015, upon which it rapidly gained popularity. Hexen, or N-ethylhexedrone, is a molecule of the substituted cathinone chemical class. The term "substituted cathinone" refers to a broad array of substances based on cathinone, the principally active constituent of the khat plant. Cathinone is principally constituted of a phenethylamine core with an alkyl group attached to the alpha carbon and an oxygen group attached to the beta carbon. Cathinones are also known as the beta-ketone (double-bonded oxygen to the β-carbon) analogs of amphetamines.

Notably, the cathinone backbone can be modified in three different places to create hundreds of possible compounds, which include substituents on the aromatic ring, the alpha carbon, and the amine group.

Hexen most likely acts as both a dopamine and norepinephrine releasing agent or reuptake inhibitor. This allows the endogenous neurotransmitters dopamine and norepinephrine to accumulate within the brain, resulting in stimulating and euphoric effects.[citation needed]

The pharmacology of N-ethylhexedrone can perhaps be compared to the much better known pentedrone. Hexedrone is an extended chain version of pentedrone, differing by a single carbon on the alpha-alkyl chain. It should be noted that extension of the carbon chain in this manner generally results in less potency than the parent compound. However, the addition of the ethyl group to the terminal amine (-NH2) group seems to counteract this and increase its potency significantly, much like is observed with NEP (N-Ethyl-(nor)-Pentedrone).

Physical effects

-Stimulation - In terms of its effects on the user's physical energy levels, Hexen can be considered to be extremely stimulating and energetic.

-Spontaneous physical sensations - As with related cathininones, it is commonly reported that medium to high doses of Hexen can produce a pleasurable "body high" characterized by pleasant tingling sensations.

-Tactile enhancement

-Vasoconstriction - A number of reports indicate, Hexen can be considered slightly vasoconstrictive, though this has yet to be scientifically demonstrated.

-Appetite suppression

-Stamina enhancement

-Dehydration Cognitive effects

-Thought acceleration

-Disinhibition

-Euphoria

-Analysis enhancement - This effect is mostly present in lower doses and is considered weak compared to other stimulant compounds. At high doses, it becomes overshadowed by euphoric stimulation.

-Immersion enhancement

-Motivation enhancement

-Time compression

-Ego inflation

-Increased music appreciation -

Compulsive redosing